Generic Name: Mebeverine Hydrochloride 135mg
Manufacturer/Distributor: Opsonin Pharma Limited
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Indications
A prescription medication called Mave 135 is used to treat and cure IBS symptoms such as stomach discomfort and spasms, cramping in the abdomen, gas, bloating, and changes in bowel patterns. The intestine's muscles are relaxed by this medication, which also relieves spasms.
Pharmacology
Mebeverine hydrochloride is the hydrochloride salt of mebeverine, an oral biologic Reserpin dependent agent and a specialized anticholinergic, with constrictive motion. When organized, target mebeverine binds to muscarinic receptors and classifies them in smooth muscle cells in target tissues, such as the gastrointestinal (GI) tract, uterus, gallbladder, and bladder. This prevents smooth muscle withdrawal and relaxes smooth muscle. In addition, it can predict seizures, reduce pain and spasms in the gastrointestinal tract, and improve urinary incontinence. Upon expansion, mebeverine stabilizes volatile membranes by reducing the porosity of the granular channels and preventing intracellular calcium accumulation. In addition, this operator blocks the reabsorption of norepinephrine by thinking of nerve endings and applying an anesthetic effect nearby.
Dosage & Administration
For adults, elderly, and children over 10 years:
Mebeverine Hydrochloride 135 mg tablet: 1 tablet 03 times daily.
Mebeverine Hydrochloride 200 mg capsule: 1 capsule 02 times daily.
This is most effective when taken 20 minutes before meals. After several weeks when the desired effect has been obtained, the dosage may be gradually reduced.
Missed dose: If a dose of this medicine is missed, that should be taken as soon as possible. However, if it is almost time for the next dose, then skip the missed dose and the regular dosing schedule should be maintained. The dose should not be doubled at the same time to compensate for the missed dose.
Use in children: Mebeverine is not recommended for children under 10 years.
Contraindications
Hypersensitivity to the medication or any of its components.
Side Effects
Mebeverine is generally well tolerated. However, a few adverse effects such as skin rash, urticaria, and angioedema may occur.
Pregnancy & Lactation
Animal studies have revealed no teratogenicity. However, the normal precautions for administering any medication during pregnancy should be followed. Mebeverine does not pass into breast milk once a therapeutic dose is administered.
Precautions & Warnings
Caution should be used if you have porphyria or an adverse response to this or any other drug in this class.
Storage Conditions
Store at temperatures no higher than 30°C. Keep away from light and out of children's reach.
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